Conference Summary

The Acute Kidney Injury Science Research Conference (SRC) is a 3.5-day, integrated bench to bedside conference open to the entire AKI research community focusing on topical aspects of current research and approaches in both the basic and clinical science of acute kidney injury. Attendees and invited speakers will include established investigators and trainees from academia, industry, and government agencies involved in different aspects of AKI research, with approximately equal numbers involved in clinical and basic sciences AKI research. We expect about half of the attendees will be trainees, while the remainder will be established investigators and scientists from academia, industry, and government. This meeting will provide young investigators and trainees access to leaders in the field. Networking and camaraderie among AKI investigators from academic, industry, and government backgrounds will be promoted.

Themes of the conference include: 1) understanding the cellular and molecular mechanisms involved in tissue injury, repair, and fibrosis after AKI, and the impact of co-morbidities, such as diabetes and old age, on these responses; 2) new approaches to optimize tissue acquisition, interrogation, and data integration by the Kidney Precision Medicine Program, to provide a state-of-the-art overview of the cellular and molecular heterogeneity of human AKI from human tissue interrogation studies, and to discuss how these new findings will enable us to differentiate sub-types of human AKI and might impact the development of new approaches to study mechanisms and treatment of AKI; and 3) a forum to discuss the challenges facing investigators and new approaches that are being used to optimize drug development for AKI, including the pros and cons of target-based and phenotyping drug screening, state-of-the-art pre-clinical models for drug discovery in human disease, clinical phenotyping of human AKI (including the use of biomarkers), and new approaches used for AKI clinical study design. It is anticipated that proceedings from the conference will be published in Seminar in Nephrology in early 2020.

Conference session topics will include:

  • Mechanisms injury
  • Organ interactions in AKI
  • Clinical studies in human AKI
  • Mechanisms of repair
  • Mechanisms of maladaptive repair and fibrosis
  • Human tissue interrogation in AKI
  • Immunological mechanisms of injury and repair
  • Challenges of drug development for AKI

In addition to an opening keynote lecture from Joseph Bonventre, MD, PhD (Brigham and Women's Hospital, Harvard Medical School), there will be state-of-the-art clinical and basic science lectures on acute kidney injury. The conference will feature 11 oral sessions, two poster sessions, and two evening receptions. Four career development sessions will include a career discussion panel, a small group career discussion session, and two one-on-one “Meet the Expert” lunches.

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    Funding for this conference was made possible (in part) by 1 R13 DK 121501 -01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


    Conference Location

    Asilomar Conference Grounds
    800 Asilomar Avenue
    Pacific Grove, CA 93950 USA

    Conference Organizers

    Mark de Caestecker, MB, BS, PhD
    Physician Scientist, Nephrologist, and Professor of Medicine,Vanderbilt University Medical Center, USA

    Ray Harris, MD
    Physician Scientist, Nephrologist, and Professor of Medicine Vanderbilt University Medical Center, USA

    Neil Hukriede, PhD
    Bench Scientist, Professor, and Vice Chair, Department of Developmental Biology University of Pittsburgh, USA

    Edward Siew, MD, MSCI
    Clinical Scientist, Nephrologist, and Associate Professor, Vanderbilt University Medical Center, USA

    Keynote Speaker

    Joseph Bonventre, MD, PhD
    Brigham and Women's Hospital, Harvard Medical School