Conference Summary

Launched in 2000, this biennial FASEB Science Research Conference (SRC) is celebrating its 20th anniversary. The 2019 SRC will focus on the most recent advances in immune system signaling, spanning signaling pathways that control the function of the innate and adaptive immune systems. These pathways control a wide range of biological processes, including pathogen recognition, lymphocyte activation and differentiation, trafficking, and effector function.

Participants will address new advances in our understanding of receptor triggering, kinase cascades, feedback regulation, mechanobiology, and metabolism and explore the interplay among these processes. Recent progress in these areas has provided new information that will enhance our understanding of the complex pathways that control immune responses under normal and pathogenic situations. The biological processes addressed at this conference have direct relevance to a number of clinically important areas, including autoimmunity, immunodeficiency diseases, transplantation immunology, tumor immunology, infectious diseases, and chronic inflammation.

In addition to providing a venue for interaction among basic scientists, this conference will include sessions that focus on disease diagnosis and immunotherapy. By bringing together investigators involved in basic science and translational research, we will foster collaborative interactions leading to the development of new therapeutics to treat immunological disorders. 

This conference brings together an interdisciplinary group of scientists from academic and industry backgrounds who study signal transduction in innate and adaptive immune cells. The program is designed to be valuable for established investigators as well as more junior investigators and newcomers to the field.

The main themes of this meeting are: 1) Explore the integrated molecular pathways through which pathogens and other environmental cues drive the activation and differentiation of cells of the immune system; 2) Develop a mechanistic understanding of how these signaling events control the cell biological processes associated with effector function; 3) Address genetic defects leading to immune dysregulation, and develop novel therapeutic approaches based on manipulating relevant signaling pathways.

Conference topics will include:

  • Lymphocyte signaling
  • Immune receptor activation
  • Leukocyte adhesion and migration
  • Cytoskeletal remodeling and effector function
  • Innate immune signaling
  • Nucleic acid sensing by immune cells
  • Immune signaling in health and disease
  • Modulation of immune signals

In addition to an opening keynote lecture from Ron Vale, PhD (University of California, San Francisco), this conference will feature eight oral sessions consisting of several talks from leading researchers, short talks selected from the abstracts, two poster sessions, and two career development workshops, "How to Run an Academic Lab" and "Science Policy and Community Engagement."

To be considered for a short talk, please submit your abstract by May 25, 2019.

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    Funding for this conference was made possible [in part] by 1 R13 AI144965-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


    Conference Location

    Oak Island Resort & Conference Center
    36 Treasure Drive
    Western Shore
    Nova Scotia

    Conference Organizers

    Janis Burkhardt, PhD
    Professor of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA


    Morgan Huse, PhD
    Member, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York City, NY, USA

    Greg Barton, PhD
    Professor of Immunology and Pathogenesis, University of California, Berkeley, USA

    Jeroen Roose, PhD
    Professor and Vice Chair, Anatomy, and Co-founder, ImmunoX, University of California, San Francisco, USA

    Keynote Speaker

    Ron Vale, PhD
    University of California, San Francisco