Conference Summary

Launched in 2007, this FASEB Science Research Conference (SRC) focuses on protein folding in the endoplasmic reticulum from the perspective of understanding protein folding mechanisms and the relationship between protein misfolding, pathogenesis, and cellular stress response pathways.

This conference is the major recurrent meeting for the ER/early secretory pathway research community. The attendees are an interdisciplinary group of scientists, including those from both academic and biopharmaceutical backgrounds. Both established investigators and trainees—including graduate students and postdoctoral fellows—are well represented. The overarching goal of this meeting is to understand the role of the endoplasmic reticulum in protein homeostasis in normal and pathological circumstances.

The main themes of this conference are: 1) Protein targeting, insertion, and folding mechanisms in the endoplasmic reticulum in healthy and diseased cells; 2) Cellular responses to protein misfolding in the ER including the ER associated degradation (ERAD) and the unfolded protein response (UPR) pathways; 3) The intersection between ER homeostasis and cellular and organismal function and dysfunction.

Conference session topics will include discussion on:

  • Translocation and processing of proteins in the ER
  • Protein quality control pathways in the ER
  • ER stress response pathways including the UPR
  • ER associated degradation of proteins
  • ER homeostasis in diseases including cystic fibrosis and diabetes
  • ER shape and dynamics

There will also be an emphasis on cross-disciplinary advances that link ER function to other fundamental cellular processes.

In addition to an opening keynote lecture from Tom Rapoport, PhD (Harvard Medical School), the conference will include eight oral sessions, two to three poster sessions, and two career development sessions: "The Search for Postdoctoral, Faculty and Biotech Positions" is designed for graduate students and postdoctoral fellows; "What You Didn't Learn as a Postdoc: How to Manage, Fund, and Run Your Research Lab" is designed for junior faculty.

Registration Prices

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    Conference Location

    Base Village Conference Center
    110 Carriage Way
    Snowmass Village, CO 81615 USA

    Conference Organizers

    Reid Gilmore, PhD
    Professor, Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, USA

    Thomas Rutkowski, PhD
    Associate Professor, Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, USA

    The EMBO Keynote Lecture

    Tom Rapoport, PhD
    Harvard Medical School